Diarrhea Research Today is a free monthly online journal that collates and summarizes the latest research about Diarrhea, including details on infant and child diarrhea, causes, treatment, pregnany.

First reported outbreak of diarrhea due to adenovirus infection in a hematology unit for adults.

Jalal H, Bibby DF, Tang JW, Bennett J, Kyriakou C, Peggs K, Cubitt D, Brink NS, Ward KN, Tedder RS

Clinical Microbiology & Public Health Laboratory, Addenbrooke's Hospital, Cambridge, Hills Road, Cambridge CB2 2QW, United Kingdom. hamid.Jalal@addenbrookes.nhs.uk

Numerous outbreaks of adenovirus infection from different types of health care settings, except a hematology unit, have been reported. This is the first report describing an outbreak of adenovirus infection causing diarrhea among adult hematopoietic stem cell transplant recipients. Six of 21 patients from the outbreak cohort were affected with diarrhea. Electron microscopy, cell culture, and direct DNA sequencing of amplicons generated from stool and blood samples were used to investigate this outbreak. Electron microscopy and cell culture detected adenovirus in stools from symptomatic patients. DNA sequencing of amplicons generated from stool samples confirmed nosocomial transmission of infection from a single index case. The outbreak strain was also detected in plasma of four of these patients, suggesting systemic infection. The outbreak strain was identified as type 12. Standard infection control measures were effective to control this outbreak.

Published 15 June 2005 in J Clin Microbiol, 43(6): 2575-80.
Full-text of this article is available online (may require subscription).

© 2004-2008 Diarrhea Research Today. All Rights Reserved.